Okamoto Y, Iwasaki WM, Kugou K, Takahashi KK, Oda A, Sato K, Kobayashi W, Kawai H, Sakasai R, Takaori-Kondo A, Yamamoto T, Kanemaki MT, Taoka M, Isobe T, Kurumizaka H, Innan H, Ohta K, Ishiai M, TakataM. Replication stress induces accumulation of FANCD2 at central region of large fragile genes. Nucleic Acids Res. 2018, DOI: 10.1093/nar/gky058


Sunatani Y, Kamder RP, Sharma MK, Matsui T, Sakasai R, Hashimoto M, Ishigaki Y, Matsumoto Y, Iwabuchi K. Caspase-mediated cleavage of X-ray repair cross-complementing group 4 promotes apoptosis by enhancing nuclear translocation of caspase-activated DNase. Exp. Cell Res. 2017, doi: 10.1016/j.yexcr.2017.12.009.


Sakasai R, Isono M, Wakasugi M, Hashimoto M, Sunatani Y, Matsui T, Shibata A, Matsunaga T, Iwabuchi K. Aquarius is required for proper CtIP expression and homologous recombination repair. Sci. Rep. 2017, doi:10.1038/s41598-017-13695-4


Matsui Y, Sunatani Y, Hayashi N, Okino K, Okushi Y, Mukai K, Adachi H, Yamaya H, Iwabuchi K, Yokoyama H. DNA double-strand breaks induced intractable glomerular fibrosis in renal allografts. Clin Exp Nephrol. 2016 20 (3): 479-488, doi: 10. 1007/s10157-015-1174-3.


Iimori M, Watanabe S, Kiyonari S, Matsuoka K, Sakasai R, Saeki H, Oki E, Kitao H, Maehara Y. Phosphorylation of EB2 by Aurora B and CDK1 ensures mitotic progression and genome instability. Nat. Commun. 2016, doi: 10.1038/ncomms11117.


Sakasai R and Iwabuchi K. The distinctive cellular responses to DNA strand breaks caused by a DNA topoisomerase I poison in conjunction with DNA replication and RNA transcription. Genes Genet. Syst. 2015; 90(4)


Yoo JS, Takahasi K, Ng CS, Ouda R, Onomoto K, Yoneyama M, Lai JC, Lattmann S, Nagamine Y, Matsui T, Iwabuchi K, Kato H, Fujita T. DHX36 enhances RIG-I signaling by facilitating PKR-mediated antiviral stress granule formation. PLoS Pathog. 2014 Mar 20;10(3):e1004012.


Guerra B, Iwabuchi K, Issinger OG. Protein kinase CK2 is required for the recruitment of 53BP1 to sites of DNA double-strand break induced by radiomimetic drugs. Cancer Lett. 2014 Apr 1;345(1):115-23.


Ishigaki Y, Nakamura Y, Tatsuno T, Hashimoto M, Iwabuchi K, Tomosugi N. RNA-binding protein RBM8A (Y14) and MAGOH localize to centrosome in human A549 cells. Histochem Cell Biol. 2014 Jan;141(1):101-9.


Ishigaki Y, Nakamura Y, Tatsuno T, Hashimoto M, Shimasaki T, Iwabuchi K, Tomosugi N. Depletion of RNA-binding protein RBM8A (Y14) causes cell cycle deficiency and apoptosis in human cells. Exp Biol Med. 2013 Aug 1;238(8):889-97.


Kurosawa A, Saito S, So S, Hashimoto M, Iwabuchi K, Watabe H, Adachi N. DNA ligase IV and artemis act cooperatively to suppress homologous recombination in human cells: implications for DNA double-strand break repair. PLoS One. 2013 Aug 14;8(8):e72253.



Atsumi Y, Inase A, Osawa T, Sugihara E, Sakasai R, Fujimori H, Teraoka H, Saya H, Kanno M, Tashiro F, Nakagama H, Masutani M, Yoshioka K. The Arf/p53 protein module, which induces apoptosis, down-regulates histone H2AX to allow normal cells to survive in the presence of anti-cancer drugs. J Biol Chem. 2013 May 10;288(19):13269-77.


Doai M, Watanabe N, Takahashi T, Taniguchi M, Tonami H, Iwabuchi K, Kayano D, Fukuoka M, Kinuya S. Sensitive immunodetection of radiotoxicity after iodine-131 therapy for thyroid cancer using γ-H2AX foci of DNA damage in lymphocytes. Ann Nucl Med. 2013 Apr;27(3):233-8.


Yoshida J, Iwabuchi K, Matsui T, Ishibashi T, Masuoka T, Nishio M. Knockdown of stromal interaction molecule 1 (STIM1) suppresses store-operated calcium entry, cell proliferation and tumorigenicity in human epidermoid carcinoma A431 cells. Biochem Pharmacol. 2012 Dec 15;84(12):1592-603.



Sakai A, Sakasai R, Kakeji Y, Kitao H, Maehara Y. PARP and CSB modulate the processing of transcription-mediated DNA strand breaks. Genes Genet Syst. 2012;87(4):265-72.



Sakasai R, Sakai A, Iimori M, Kiyonari S, Matsuoka K, Kakeji Y, Kitao H, Maehara Y. CtIP- and ATR-dependent FANCJ phosphorylation in response to DNA strand breaks mediated by DNA replication. Genes Cells. 2012 Dec;17(12):962-70.


Fujinaka Y, Matsuoka K, Iimori M, Tuul M, Sakasai R, Yoshinaga K, Saeki H, Morita M, Kakeji Y, Gillespie DA, Yamamoto K, Takata M, Kitao H, Maehara Y. ATR-Chk1 signaling pathway and homologous recombinational repair protect cells from 5-fluorouracil cytotoxicity. DNA Repair. 2012 Mar 1;11(3):247-58.


橋本 (砂谷) 優実, 岩淵邦芳. アポトーシスとDNA二本鎖切断(DSB)修復因子. 放射線生物研究 2011 Dec;46(4), 311-321.


橋本 (砂谷) 優実. ショウジョウバエヘモサイトによる黄色ブドウ球菌貪食におけるDraperのリガンドとしてのリポタイコ酸の同定. 金沢大学十全医学会雑誌 2010 Jun;119(2), 38-39.


Sakasai R, Teraoka H, Takagi M, Tibbetts RS. Transcription-dependent activation of ataxia telangiectasia mutated prevents DNA-dependent protein kinase-mediated cell death in response to topoisomerase I poison. J Biol Chem. 2010 May 14;285(20):15201-8.    


Masaki H, Nishida T, Sakasai R, Teraoka H. DPPA4 modulates chromatin structure via association with DNA and core histone H3 in mouse embryonic stem cells. Genes Cells. 2010 Apr 1;15(4):327-37.


Shiratsuchi A, Shimizu K, Watanabe I, Hashimoto (Sunatani) Y, Kurokawa K, Razanajatovo IM, Park KH, Park HK, Lee BL, Sekimizu K, Nakanishi Y. Auxiliary role for D-alanylated wall teichoic acid in Toll-like receptor 2-mediated survival for Staphylococcus aureus in macrophages. Immunology. 2010 Feb;129(2):268–277.


Sakasai R, Teraoka H, Tibbetts RS. Proteasome inhibition suppresses DNA-dependent protein kinase activation caused by camptothecin. DNA Repair (Amst). 2010 Jan 2;9(1):76-82.


Kuraishi T, Nakagawa Y, Nagaosa K, Hashimoto (Sunatani) Y, Ishimoto T, Moki T, Fujita Y, Nakayama H, Dohmae N, Shiratsuchi A, Yamamoto N, Ueda K, Yamaguchi M, Awasaki T, Nakahishi Y. Pretaporter, a Drosophila protein serving as a ligand for Draper in the phagocytosis of apoptotic cells. EMBO J. 2009 Dec 16;28(24):3868–78.


Hashimoto (Sunatani) Y, Tabuchi Y, Sakurai K, Kutsuna M, Kurokawa K, Awasaki T, Sekimizu K, Nakanishi Y, Shiratsuchi A. Identification of lipoteichoic acid as a ligand for Draper in the phagocytosis of Staphylococcus aureus by Drosophila hemocytes. J Immunol. 2009 Dec 1;183(11):7451-60.


Watanabe K, Iwabuchi K, Sun J, Tsuji Y, Tani T, Tokunaga K, Date T, Hashimoto M, Yamaizumi M, Tateishi S. RAD18 promotes DNA double-strand break repair during G1 phase through chromatin retention of 53BP1. Nucleic Acids Res. 2009 Apr;37(7):2176-93.


Hashimoto M, Matsui T, Iwabuchi K, Date T. PKU-beta/TLK1 regulates myosin II activities, and is required for accurate equaled chromosome segregation. Mutat Res. 2008 Nov 17;657(1):63-7.


Iwabuchi K, Matsui T, Hashimoto M, Matsumoto Y, Kurihara T, Date T. Characterization of a cancer cell line that expresses a splicing variant form of 53BP1: separation of checkpoint and repair functions in 53BP1. Biochem Biophys Res Commun. 2008 Nov 21;376(3):509-13.


Iwabuchi K, Hashimoto M, Matsui T, Kurosawa A, Adachi N, Date T. Cell sorting analysis of cell cycle-dependent X-ray sensitivity in end joining-deficient human cells. Biochem Biophys Res Commun. 2008 Aug 8;372(4):662-7.


Sakasai R and Tibbetts R. RNF8-dependent and RNF8-independent regulation of 53BP1 in response to DNA damage. J Biol Chem. 2008 May 16;283(20):13549-55.


Kobayashi J, Iwabuchi K, Miyagawa K, Sonoda E, Suzuki K, Takata M, Tauchi H. Current topics in DNA double-strand break repair. J Radiat Res. 2008 Mar;49(2):93-103.


Nakanishi Y, Hashimoto (Sunatani) Y, Takizawa T, Shiratsuchi A. Mechanisms and consequences of phagocytosis of influenza virus-infected cells. Anti Inflamm Anti Allergy Agents Med Chem. 2008; 7(2):97-100.


Matsumoto M, Yaginuma K, Igarashi A, Imura M, Hasegawa M, Iwabuchi K, Date T, Mori T, Ishizaki K, Yamashita K, Inobe M, Matsunaga T. Perturbed gap-filling synthesis in nucleotide excision repair causes histone H2AX phosphorylation in human quiescent cells. J Cell Sci. 2007 Mar 15;120(Pt 6):1104-12.


Hashimoto (Sunatani) Y, Moki T, Takizawa T, Shiratsuchi A, Nakanishi Y. Evidence for phagocytosis of influenza virus-infected, apoptotic cells by neutrophils and macrophages in mice. J Immunol. 2007 Feb 15;178(4):2448-57. ("Faculty of 1000 Biology")


Iwabuchi K, Hashimoto M, Matsui T, Kurihara T, Shimizu H, Adachi N, Ishiai M, Yamamoto K, Tauchi H, Takata M, Koyama H, Date T. 53BP1 contributes to survival of cells irradiated with X-ray during G1 without Ku70 or Artemis. Genes Cells. 2006 Aug;11(8):935-48.


Kawamura K, Morita N, Domiki C, Fujikawa-Yamamoto K, Hashimoto M, Iwabuchi K, Suzuki K. Induction of centrosome amplification in p53 siRNA-treated human fibroblast cells by radiation exposure. Cancer Sci. 2006 Apr;97(4):252-8.


Sakasai R, Shinohe K, Ichijima Y, Okita N, Shibata A, Asahina K, Teraoka H. Differential involvement of phosphatidylinositol 3-kinase-related protein kinases in hyperphosphorylation of replication protein A2 in response to replication-mediated DNA double-strand breaks. Genes Cells. 2006 Mar;11(3):237-46.